Our Mission - CCL is a research facility dedicated to:
Computational Chemodynamics and Toxicodynamics
This involves the development, computational implementation,
and application/evaluation of physically and physiologically based
mathematical models of chemodynamic (environmental) and toxicodynamic
(biological) processes (research area of mechanistic/prognostic
modeling).
Environmental and Biological Informatics
This involves the development and/or application of computational
tools for the mining, pattern recognition, and statistical analysis/interpretation
of large, multivariate, environmental and biological datasets,
with emphasis on environmental indicators and toxicogenomics applications
(research area of phenomenological/diagnostic modeling).
Objective of the research efforts at CCL is the improvement of procedures for:
- Predicting transport/fate and quantifying concentrations/depositions of chemicals in multimedia environments (environmental modeling).
- Estimating multiroute/multipathway exposures of individuals and populations to toxics in various indoor and outdoor microenvironments (exposure modeling).
- Estimating internal doses for appropriate target tissues, using physiologically-based transport and toxicokinetic modeling (biological dosimetry modeling).
- Optimizing the information that can be extracted from complex datasets relevant to systems that involve environment-organism interactions (enviroinformatics and bioinformatics).
CCL's efforts include exploring computer simulation-based alternatives to animal testing for risk assessment.
