Recent and Upcoming Activities of ebCTC

2009

12/3/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• The role of pharmacokinetic modeling in toxicity testing (Michael DeVito, USEPA)

11/12/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Estrogen and breast cancer (Jose Russo, Fox Chase Cancert Center)

11/8-13/2009
Annual Meeting of American Institute of Chemical Engineers, Nashville, TN. Presentations by ebCTC researchers:

• Understanding mechanisms of conazole toxicity in cultured hepatocytes (V.V. Iyer, M.G. Ierapetritou, C.M. Roth)

11/5/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Environmental arsenic signals for pathogenic vascular remodeling (Aaron Barchowsky, University of Pittsburgh)

11/1-5/2009
2009 Annual Conference of ISES, Minneapolis, MN (ebCTC researcher Sastry Isukapalli is chairing a symposium "Integrative Exposure Biology and Computational Toxicology for Risk Assessment") Presentations by ebCTC researchers:

• Linking exposure dynamics with health effects through biological modeling: Case study with TCE exposure and oxidative stress (C.J. Brinkerhoff, P.G. Georgopoulos) [abstract]
• Integrative source-to-dose-to-effect modeling for interpreting biomonitoring data in an exposure context (P.G. Georgopoulos, S.S. Isukapalli) [abstract]
• Multiscale mechanistic models in exposure assessment: Case studies with virtual organs (S.S. Isukapalli) [abstract]
• Pathway modeling of microarray data of the rat testes after in utero DBP exposure (M. Ovacik, M.G. Ierapetritou, P. Georgopoulos, W. Welsh, S. Euling, B. Sen, K. Gaido, I.P. Androulakis) [abstract]
• Integrated computational models for supporting risk assessment: case studies with chemical mixtures (A.F. Sasso, K. Krishnan, S.S. Isukapalli) [abstract]
• Biological spectra profile analysis in computational toxicology: Linking the bioactivities and molecular structures of chemical datasets (W.J. Welsh) [abstract]

10/28-30/2009
4th International Conference on Oxidative/Nitrosative Stress and Disease, New York Academy of Science (NYAS), New York, NY. Presentations by ebCTC researchers:

• Integrative modeling of chemically induced oxidative stress: A case study with trichloroethylene (C.J. Brinkerhoff, S.S. Isukapalli, P.G. Georgopoulos)

10/22/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Type XV collagen: features and proposed functions of novel collagen/proteoglycan (Peter Amenta, UMDNJ-RWJMS)

10/8/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Visual effects of organic solvents: acute, chronic and extrapolation modeling (William K. Boyes, USEPA)

10/1/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Metabolic basis of perfluoroalkyl acid toxicity (Kenneth Wallace, University of Minnesota Medical School)

10/1/2009
Computational Toxicology Centers Science to achieve Results (STAR) Progress Review Workshop USEPA Main Campus, Research Triangle Park, NC. Scientists from EPA's STAR Computational Toxicology and Bioinformatics Centers will present their research findings to date and future endeavors.

• Environmental Bioinformatics and Computational Toxicology Center (ebCTC): Research in multiscale modeling of the effects of environmental toxicants (W.J. Welsh, P.G. Georgopoulos)

9/29-30/2009
USEPA Board of Scientific Counselors Computational Toxicology Review. USEPA Main Campus, Research Triangle Park, NC. Presentations by ebCTC researchers:

• Environmental Bioinformatics and Computational Toxicology Center (ebCTC): Research collaborations with USEPA in multiscale modeling of the effects of environmental toxicants (W.J. Welsh, P.G. Georgopoulos)

9/24/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• All particles, great and small (Lung Chi Chen, NYU School of Medicine)

9/20-23/2009
5th International Conference on Toxicogenomics (ICT)
and 2nd Toxicogenomics Integrated Environmental Science (TIES), Seoul, Korea (ebCTC researcher Weida Tong is chairing a session on "MicroArray Quality Control")

9/2-6/2009
31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2009), Minneapolis, MN (ebCTC researcher Ioannis Androulakis is co-chairing a session on"Advances in Theory and Clinical Applications of Biological Network Studies") Presentations by ebCTC researchers:

• A unified multiscale field/network/agent based modeling framework for human and ecological health risk analysis (P.G. Georgopoulos, S. Isukapalli)
• Nonlinear bionetwork structure inference using the random sampling-high dimensional model representation (RS-HDMR) algorithm (M. Miller, X. Feng, G. Li, H. Rabitz)

8/30-9/4/2009
10th Annual Conference on Systems Biology (ICSB 2009), Stanford, CA. Presentations by ebCTC researchers:

• An integrated mathematical model for studying toxicokinetic and toxicodynamic processes following exposures of human hepatocytes to arsenic compounds (S.K. Stamatelos, C.J. Brinkerhoff, S.S. Isukapalli, P.G. Georgopoulos) [abstract]

5/20/2009
3rd Annual SYSTEMS TOXICOLOGY SYMPOSIUM
presented by ebCTC at EOHSI, Piscataway, NJ.
Free and open to the research community

5/14-15/2009
First ToxCast Data Analysis Summit (TDAS), USEPA Campus, Research Triangle Park, NC (ebCTC researchers Weida Tong and William Welsh are among the organizing committee). Presentations by ebCTC researchers:

Presentations

• Biological profile analysis of the ToxCast chemicals: Linking biological activity profiles to molecular structure (W.J. Welsh)
• Predicting in vivo toxicities using optimal methods for re-ordering and machine learning (P.A. DiMaggio, C.A. Floudas*, J.D. Rabinowitz, H.A. Rabitz) *presenter
• Prediction of liver toxicity in the animal study using the mechanistically relevant in vitro screening assay data – Lessens learned from the EPA ToxCast project (Z. Su, H. Hong, W. Tong*) *presenter

Posters

• Data needs for progressing from hazard characterization to risk assessment: Analysis focusing on chemicals from the ToxCast database (C.J. Brinkerhoff, J.A. Alexander, C.T. Yung, S.S. Isukapalli, P.G. Georgopoulos)
• Exposure reconstruction from biomonitoring data using screening level approaches: application to chemicals in the ToxCast database (C.J. Brinkerhoff, J.A. Alexander, A.F. Sasso, S.S. Isukapalli, P.G. Georgopoulos)
• Progress in the development of ebTrack, an open environmental bioinformatics system: design considerations related to the support of consistent multi-attribute ToxCast data analyses (P.G. Georgopoulos, M. Chen, S.S. Isukapalli, W. Welsh, W. Tong)
• Relating toxicity profiles to molecular structures: A preliminary analysis of the transcription factor assays data from Attagene Inc. (D. Chekmarev, V. Kholodovych, N. Ai, P.G. Georgopoulos, W. Tong, W.J. Welsh)

5/11-13/2009
Toxicity Pathway Based Risk Assessment: Preparing for Paradigm Change. The National Academy of Sciences, Washington, DC. Presentations by ebCTC researchers:

• Application of an integrated bioinformatics system for pathway-based analysis of toxicity data (S. Isukapalli, D. Gerecke, Y.C.  Chang, M. Chen, I. Androulakis, W. Welsh, W. Tong, P.G. Georgopoulos)
• Dissecting enzyme regulation by multiple allosteric effectors using the random sampling – high dimensional model representation algorithm (J. Rabinowitz, J. Hsiao, K. Gryncel, E. Kantrowitz, X. Feng, G.Li, H. Rabitz)
• Metabolic flux analysis: Understanding mechanisms of conazole toxicity in cultured hepatocytes (V. Iyer, I. Androulakis , C.M. Roth, M.G. Ierapetritou)
• Toxicity pathway modeling of chemically induced oxidative stress: A case study with trichloroethylene (C.J. Brinkerhoff, S.S. Isukapalli, P.G. Georgopoulos)

5/6/2009
EOHSI/NIEHS Seminar Series (Kuna Lecture), EOHSI Room C, Rutgers Busch Campus, 4 PM

• Complex responses to DNA damaging agents (Leona Samson, MIT Center for Environmental Health Sciences)

5/5/2009
Exposure Science Community of Practice Teleconference. USEPA Campus, RTP, NC, 11 AM

• Connecting environment, biology, and behavior for human exposure and risk assessment: Integrative modeling approaches (P.G. Georgopoulos)

4/30/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Halting the progression of neurodegenerative diseases: What does Nrf2 have to do with it? (Jeffery Johnson, University of Wisconsin)

4/23/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Impaired coronary artery function following short-term diesel exhaust inhalation (Nancy Kanagy, University of New Mexico)

4/21-23/2009
v-Tissue 2009: The EU-US Workshop on Virtual Tissues. USEPA, Research Triangle Park, NC. Presentation by ebCTC researcher:

• Frameworks for linking exposure, dosimetry and toxicity (P.G. Georgopoulos)

3/26/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Mechanisms and prevention of tobacco-induced cancer: Recent studies (Stephen Hecht, University of Minnesota)

3/20/2009
ebCTC Science Day, EOHSI Room 402, Rutgers Busch Campus, 12 PM

• Role of autophagy in mammary tumorigenesis (Vassiliki Karantza-Wadsworth, UMDNJ-RWJMS and Cancer Institute of NJ)

3/18/2009
Cancer Institute of NJ, Genetic Epidemiology and Population Biology Research Program Meeting, Institute for Advanced Studies, Princeton, NJ

• Environmental carcinogens and exposure biology challenges (P.G. Georgopoulos)

3/15-19/2009
48th Annual Meeting of the Society of Toxicology (SOT), Baltimore, MD. Presentations by ebCTC researchers:

• A novel algorithm for computing interaction-based hazard index for the health risk assessment of chemical mixtures (S.S. Isukapalli, A.F. Sasso, P.G. Georgopoulos, K. Krishnan) [abstract]
• An integrated species comparison analysis based on biological pathways (M. Ovacik, S. Euling, B. Sen, P.G. Georgopoulos, M.G. Ierapetritou, I.P. Androulakis) [abstract]
• Temporal pathway activity analysis of transcriptional profiling of in utero exposure to d-n-butyl phthalate (M. Ovacik, M.G. Ierapetritou, P.G. Georgopoulos, W. Welsh, S. Euling, B. Sen, K. Gaido, I.P. Androulakis) [abstract]

3/13-17/2009
Annual Meeting of the American Academy of Allergy, Asthma, and Immunology, Washington, DC. Presentation by ebCTC researchers:

• A modeling system for supporting population exposure assessment to bioaerosols and other air pollutants (S.S. Isukapalli, C. Efstathiou, L.J. Bielory, P.G. Georgopoulos) [abstract]

3/6/2009
ebCTC Science Day, EOHSI Room 402, Rutgers Busch Campus, 12 PM

• Discovery of novel microRNA-encoding genes in human embryonic stem cells by SOLiD deep sequencing (Ronald Hart, W.M. Keck Center for Collaborative Neuroscience)

3/5/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Epigenetic mechanisms of metal carcinogenesis (Max Costa, NYU School of Medicine)

3/4/2009
Rutgers Department of Pharmacy Seminar, Ernest Mario School of Pharmacy, Room 111, Rutgers Busch Campus, 12 PM

• Elucidating the 'Jekyll and Hyde' nature of PXR: The case for discovering antagonists (Sean Ekins, Collaborative Drug Discovery, Inc. and ebCTC)

2/26/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Human pulmonary and cardiovascular effects of very small particles (Mark Frampton, University of Rochester)

2/19/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Human fetal testis xenotransplants and endocrine disruptions (Kim Boekelheide, Brown University)

2/5/2009
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Endocrine disruption within the HPG axis by bisphenol-a and soy (Heather Patisaul, North Carolina State University)

1/18-21/2008
Second International Conference on Biomolecular Engineering, Santa Barbara, CA. Presentation by ebCTC researchers:

• Multiscale physiologically based toxicokinetic (PBTK) modeling: A case study for arsenic compounds (S.K. Stamatelos, C.J. Brinkerhoff, A.F. Sasso, S.S. Isukapalli, P.G. Georgopoulos) [abstract]
• Approaches towards a reversed engineered model of systemic inflammation in humans (P.T. Foteinou, S.E. Calvano, S.F. Lowry, I.P. Androulakis) [abstract]

2/13/2009
Biostatistics Seminar, UMDNJ School of Public Health Room 3A/3B, Busch Campus, 3:00 PM

• Addressing heterogeneity in the analysis of clinical genomics studies (John Storey, Princeton University)

1/13/2009
EOHSI Seminar, EOHSI Room A-B, Rutgers Busch Campus, 1:30 PM

• Urban residential pyrethroid insecticide use during pregnancy and effects on infant neurodevelopment (Megan K. Williams, Columbia University)

1/13/2009
CABM Seminar, CABM Room 010, Rutgers Busch Campus, 12:00 PM

• Growth control by fat in flies and mice (Helen McNeill, University of Toronto)

2008

12/15/2008
UMDNJ-RWJMS Seminar, RWJMS, Rutgers Busch Campus, Room V10, 4 PM

• Transcriptional corepressors in development and diseases (Chih-Cheng Tsai, UMDNJ-RWJMS)

12/15/2008
Human Genetics Institute Seminar, Life Sciences Bldg. Auditorium, Rutgers Busch Campus, 12 pm

• Understanding inherited genetic susceptibility to cancer (Robert Klein, Memorial Sloan Kettering Cancer Center)

12/12/2008
Cell Biology and Neuroscience Seminar, Nelson Room B228, Rutgers Busch Campus, 12 PM

• Regulating nicotinic synapses in the nervous system (Joseph Margiotta, University of Toledo Medical Center)

12/11/2008
UMDNJ Seminar, UMDNJ Tower, V10, Busch Campus, 4:00 pm

• Design of Tunable Proteins via Phosphorylation, Electronics and Stereoelectronic Effects (Neal Zondlo, University of Delaware)

12/08/2008
CABM Seminar, CABM 010, Rutgers Busch Campus, 12:00 pm

• The NIH Protein Structure Initiative: Achievements and Visions for the Future (Gaetano Montelione, Rutgers University)

12/7-10/2008
Society of Risk Analysis (SRA) 2008 Annual Meeting, Boston, MA. Presentation by ebCTC researchers:

• A novel interaction-based algorithm for predicting biological doses during chronic exposures to chemical mixtures (S.S. Isukapalli, A.F. Sasso, P.G. Georgopoulos, K. Krishnan) [abstract]

12/5/2008
NJ Universities Homeland Security Research Consortium, Princeton, NJ. Presentation by ebCTC researchers:

• Computational modeling for supporting emergency event response: population exposures to anthrax (S.S. Isukapalli, P.J. Lioy, P.G. Georgopoulos) [abstract]
• Bioinformatics techniques for disease detection and finding medical countermeasures: Case study with sulfur mustard (D.R. Gerecke, M. Chen, S.S. Isukapalli, M.K. Gordon, Y.C. Chang. W. Tong, I.P. Androulakis, P.G. Georgopoulos) [abstract]

11/26/2008
ChemBioE Seminar, BME Room 122, Rutgers Busch Campus, 10:20 am

• Molecular systems biology: Building bridges through multiscale modeling and high-performance computing (R. Radhakrishnan)

11/25/2008
EOHSI Seminar, EOHSI A&B, Rutgers Busch Campus, 1:30 pm

• Environmental Carcinogenesis (Michael Gallo, EOHSI)

11/16-21/2008
2008 AIChE Annual Meeting, Philadelphia, PA. Presentations by ebCTC researchers:

• Physiologically-based inhalation dosimetry modeling for nanoparticles: Considerations of activity, age, and gender [abstract]
• In silico modeling of uptake and metabolism of arsenicals in hepatocytes with implications for hepatotoxicity [abstract]
• Indirect response model of arsenic exposure on gene expression [abstract]
• Effects of glucose and insulin levels on HepG2 cell metabolism [abstract]
• Effects of hormone and amino acid supplementation in optimal liver specific functions of hepatocytes [abstract]
• De novo protein design of complement 5a [abstract]
• A novel mixed-integer linear optimization framework for the identification of post-translationally modified proteins using ETD/ECD tandem mass spectrometry [abstract]
• De novo protein design based on binding affinity predictions for the discovery of novel inhibitors for Complement 3 and HIV-1 [abstract]
• De novo identification of biomarker proteins using tandem mass spectrometry [abstract]
• A novel approach for residue contact prediction in beta and alpha/beta proteins [abstract]
• Single sequence secondary structure prediction for globular proteins [abstract]

11/6/2008
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Differential regulation of the notch-hes1-mash1 signaling pathway during gestational lead exposure selectively increases the number of late-born retinal neurons, but not Muller Glial cells (Donald Fox, University of Houston)

10/29/2008
ChemBioE Seminar, BME Room 122, Rutgers Busch Campus, 10:20 AM

• Elucidating the control mechanism for DNA damage repair with the p53-Mdm2 system: single cell data analysis and ensemble modeling (B. Ogunnaike)

10/23/2008
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Scavenger receptors in regulating lung inflammation (Andrij Holian, University of Montana)

10/22/2008
Cancer Institute Seminar, The Cancer Institute of New Jersey, Auditorium A, 4:00 PM

• How the Genome and the Computer are Changing Biomedical Science (David Botstein, Lewis-Sigler Institute for Integrative Genomics)

10/15/2008
ChemBioE Seminar, BME Room 122, Rutgers Busch Campus, 10:20 AM

• Dynamic flux balance models for genome-scale analysis and optimization of yeast metabolism (M. Henson)

10/12-16/2008
ISEE/ISEA 2008 Conference, Pasadena, CA. Presentation by ebCTC researchers:

• Model estimates of arsenic exposure and dose and evaluation with 2003 NHANES data (J. Xue, V. Zartarian, S.W. Wang, P.G. Georgopoulos) [abstract]

10/8/2008
BioMaPS Lecture Series, Fiber Optics Auditorium, Rutgers Busch Campus, 4 PM

• On Inverse Problems in Biology (S. Liebler, Rockefeller University)

10/3/2008
ebCTC Science Day at EOHSI. Presentations and discussions on "Computational toxicology studies on interactions of the hepatic nuclear receptor PXR with xenobiotics" led by Drs. Sean Ekins and William Welsh

10/1/2008
BioMaPS Lecture Series, Hill Center, Room 260, Rutgers Busch Campus, 1:30 PM

• Decoding the regulatory genome and proteome (O. Elemento, Princeton University)

9/24/2008
Gould Lecture Series in Molecular and Cellular Medicine, Child Health Institute of New Jersey, Room 3101, 89 French Street, New Brunswick

• Control of Stem Cells (Stuart H. Orkin, MD, Harvard Medical School)

9/22/2008
PhD Thesis Defense, Room 122 of the Biomedical Engineering Building at Rutgers Busch Campus, 2 PM

• A Systems Biology Approach for Assessing Corticosteroid Activity(ebCTC researcher Eric Yang; Thesis Advisor: Professor Ioannis Androulakis)
  

9/18/2008
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• Cerebellar Granule Neuron Precursors are Targets for Dioxin Exposure: Does the Aryl Hydrocarbon Receptor Play a Role in Neurogenesis? (L. Opanashuk, Univ. of Rochester Medical School)

9/15/2008
BioMaPS Lecture Series, Biomedical Engineering, Room 102, Rutgers Busch Campus, 1:30 PM

• Computational systems bioengineering: From molecules to networks to cells (J. Liang, University of Illinois-Chicago)

9/11/2008
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus, 12 PM

• The role of age and gender in the genetic susceptibility to inhaled pollutants - animal models (T. Gordon, NYU School of Medicine)

9/10/2008
BioMaPS Lecture Series, Center for Advanced Biotechnology & Medicine, Rutgers Busch Campus, Room 010, 12 PM

• Structural Studies of Neurotrophic Factors and Their Ligands (A Goldman, University of Helsinki)

9/3/2008
BioMaPS Lecture Series, Hill Center, Room 260, Rutgers Busch Campus, 1:30 PM

• Molecular Characteristics of Renal Cell Carcinoma Contributing to Response to Targeted Therapy (W. Kimryn Rathmell - University of North Carolina)

6/29-7/3/2008
Protection and Restoration of the Environment IX (PRE9) Conference, Kefalonia, Greece. Presentations by ebCTC researcher:

• Mechanistic studies of environmental causes of human disease: a bionetwork dynamics modeling approach (P.G. Georgopoulos) [abstract]

5/14/2008
CABM Seminar, Center for Advanced Biotechnology and Medicine, Rutgers Busch Campus, Room 01, 12:00 PM0

• Mechanisms of post-transcriptional gene control (J. Manley, Columbia University)

5/7/2008
Miller Distinguished Lecture, Ernest Mario School of Pharmacy, Rutgers Busch Campus

• Mechanism of action of non-genotoxic hepatocarcinogens (Frank J. Gonzalez of NIH)

4/30-5/1/2008
2nd Annual SYSTEMS TOXICOLOGY SYMPOSIUM:
Multiscale Modeling, from Molecules to Organisms
A symposium presented by ebCTC at EOHSI, Piscataway, NJ. Free and open to the research community - over 100 attendees registered.

4/25/2008
Ernest Mario School of Pharmacy Seminar, Rutgers Busch Campus, Piscataway, NJ.

• Interactions between the aryl hydrocarbon receptor (AhR) and Ras/Raf signaling pathways in human melanoma cells (Lori White, Rutgers University)

4/14-17/2008
International Conference on Health Sciences Simulation, Ottawa, Canada. Presentation by ebCTC reserchers:

• A physiologically-based algorithm for predicting internal dose of inhaled toluene: applications for high dose to low dose and rodent to human extrapolations (S.S. Isukapalli, K. Price, P.G. Georgopoulos, K. Krishnan) [abstract]

3/18/2008
SOT Annual Meeting & ToxExpo 2008, Seattle, WA. Presentation by ebCTC reserchers:

• Toxicogenomic studies reveal the transsulfuration pathway as a possible mechanism for liver toxicity (M. Chen, L.K. Schnackenberg, R. Holland, R.D. Beger, Q. Shi, S. Isukapalli, P.G. Georgopoulos, W. Welsh, W. Tong) [presentation]

3/12/2008
*Computational Toxicology Seminar, USEPA, Research Triangle Park, NC. Presentation by ebCTC resercher:

• From data to models: Systems biology methods and potential applications to toxicoinformatics (I. Androulakis) [presentation]

2/28/2008
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus

• Mutagenicity of air and water: mechanisms and biomarkers (David DeMarini, USEPA Environmental Carcinogenesis Division)

2/23-24/2008
MCBIOS 2008, Oklahoma City, OK

• Toxicogenomic studies reveal biosynthetic pathway of S-adenosylmethione as a possible hepatotoxic mechanism (M. Chen, L.K. Schnackenberg, L. Guo, R. Holland, R.D. Beger, Q. Shi, S. Isukapalli, P.G. Georgopoulos, W. Welsh, W. Tong) [abstract]

1/29-30/2008
ebCTC Science Days at EOHSI. An informal 2-day workshop with ebCTC researchers - "The path from ArrayTrack to ebTRack - Progress, Applications and Future Plans"

1/22/2008
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus

• Synthetic Biology for Bioinformatics (Max Garzon, University of Memphis)

2007

October-December 2007

12/20/2007
*Computational Toxicology Seminar, USEPA, Research Triangle Park, NC. Presentations by ebCTC reserchers:

• Optimal identification and analysis of bionetworks and biomolecules (Herschel Rabitz, Xiao-Jiang Feng) [presentation]
• Molecular modeling studies of interactions between xenobiotics and liver nuclear receptors (W.Welsh) [presentation]

12/6/2007
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus

• PBPK Modeling of Interactions and Risk Assessment of Chemical Mixtures (Kannan Krishnan, University of Montreal and visiting scholar at EOHSI)

11/4-9/2007
AIChE Annual Meeting, Salt Lake City, UT. Presentations by ebCTC reserchers:

• Toxicogenomics analysis following in utero exposure to di-butyl-phthalate (M.A. Ovacik, M.G. Ierapetritou, B. Sen, S. Euling, P.G. Georgopoulos, W. Welsh, K.W. Gaido, I.P. Androulakis) [abstract]
• A systematic toxicokinetic modeling framework for mixtures of toxic metals (A.F. Sasso, S.S. Isukapalli, P.G. Georgopoulos) [abstract]

11/1/2007
EOHSI/NIEHS Seminar Series, EOHSI Room C, Rutgers Busch Campus

• Genetical Genomics and Liver Toxicology: Making New Friends (Yvan Rusyn, Carolina Bioinformatics Center)

10/26/2007
Society of Environmental Toxicology and Chemistry (SETAC) Fall Workshop - Environmental Risk Assessment of Metals and Metalloids, Camden, NJ. Presentations by ebCTC reserchers:

• Integrating enviroinformatic and bioinformatic approaches for the systematic analysis of environmental human health risks from metals and metalloids (P.G. Georgopoulos, A.F. Sasso, S.S. Isukapalli) [abstract]
• Consistent physiologically based toxicokinetic modeling for mixtures of toxic metals and metalloids (A.F. Sasso, S.S. Isukapalli, P.G. Georgopoulos) [abstract]

10/25-26/2007
First International Conference on Toxicogenomics Integrated with Environmental Sciences (TIES), Raleigh, NC. Presentations by ebCTC reserchers:

• Pathway activity analysis for transcriptional profiling of in utero exposure to d-n-butyl phthalate (M.A. Ovacik, M.G. Ierapetritou, P.G. Georgopoulos, W. Welsh, S. Euling, B. Sen, K. Gaido, I.P. Androulakis) [abstract]
• ebTrack: an environmental bioinformatics system built upon ArrayTrack (M. Chen, S.S. Isukapalli, P.G. Georgopoulos, W.J. Welsh, W. Tong) [abstract]

10/14-18/2007
17th Annual Meeting of the International Society of Exposure Analysis, Durham, NC. Presentations by ebCTC reserchers:

• Modeling personal and ambient exposures to air toxics in Camden, New Jersey (S.W. Wang, X. Tang, Z. Fan, P.J. Lioy, P.G. Georgopoulos) [abstract]
• Systems toxicology: multiscale modeling of environmental impacts on bionetworks (W.J. Welsh, P.G. Georgopoulos) [abstract]
• Exposure biology for a systems approach in studying environmental health risks (P.G. Georgopoulos, S.S. Isukapalli, W. Tong, P.J. Lioy, W.J. Welsh) [abstract]
• Comparative evaluation of population exposure modeling approaches for reactive and non-reactive air pollutants (S.S. Isukapalli, J.E. Langstaff, D.J. Lucken, P.G. Georgopoulos) [abstract]
• Characterizing chemical exposure from biomonitoring data using the Exposure Related Dose Estimating Model (ERDEM) (C.C. Dary, P.G. Georgopoulos, D.A. Vallero, R. Tornero-Velez, M. Morgan, M. Okino, M. Dellarco, F. Power, J.N. Blancato) [abstract]
• Characterizing exposures to arsenic and co-occurring contaminants using the Modeling Environment for TOtal Risk studies (MENTOR) (P.G. Georgopoulos, S.W. Wang, A.F. Sasso, S.S. Isukapalli) [abstract]
• Comparative evaluation of screening and computational fluid dynamics (CFD) approaches for modeling inhalation exposures in indoor environments (S.K. Stamatelos, P.G. Georgopoulos) [abstract]
• Comparative evaluation of three statistical data mining techniques (CART, MARS, and Random Forest) and their applications in analyzing the NHANES VOC project data (S.W. Wang, Y. Yan, P.G. Georgopoulos) [abstract]
• Sensitivity analysis for studying impacts of aging on population toxicokinetics and toxicodynamics (A.F. Sasso, S.S. Isukapalli, E. Kenyon, P.G. Georgopoulos) [abstract]
• Physiologically based toxicokinetic modeling for mixtures of toxic metals (A.F. Sasso, S.S. Isukapalli, P.G. Georgopoulos) [abstract]
• Evaluation of methods for reconstructing exposures from biomarkers via PBTK models (S.S. Isukapalli, A.F. Sasso, M. Okino, P.G. Georgopoulos) [abstract]

10/9/2007
ebCTC Science Day: Researchers from the Princeton group lead presentations and discussions on Biological Network Dynamics in an informal session at EOHSI

July-September 2007

8/23/2007
ebCTC Science Day: Researchers from the Rutgers and UMDNJ groups lead discussions and presentations on Modeling of Chemical-Induced Carcinogenesis, at the Rutgers Department of Biomedical Engineering.

April-June 2007

5/21-23/2007
2007 International Science Forum on Computational Toxicology: Sponsored by USEPA at their main campus in Research Triangle Park, NC. ebCTC scientists presented several posters and also had a booth to present and discuss their work.

5/11/2007 and 5/18/2007
ebCTC Science Days: Researchers from the UMDNJ and Rutgers groups lead discussions and presentations on "virtual liver" technology in informal sessions at EOHSI.

4/26-27/2007
SYSTEMS TOXICOLOGY: Multiscale Modeling of Environmental Impacts on Bionetworks: A symposium presented by ebCTC and DIMACS, open to the research community

4/11/2007
*Computational Toxicology Seminar, USEPA, Research Triangle Park, NC. Presentation by ebCTC reserchers:

• Incorporating toxicogenomic data and approaches in risk assessment: Case study - phthalate esters (M. Ovacik, M.G. Ierapetritou, I.P. Androulakis, B. Sen, S. Euling, K. Gaido, P.G. Georgopoulos, W. Welsh) [presentation]

January-March 2007

3/14/2007
*Computational Toxicoloy Seminar: Optimization Tools for in silico Proteomics (P.A. DiMaggio Jr., C.A. Floudas)

2/28-3/1/2007
ebCTC Science Days: The Science and Technology for a "Virtual Liver": An informal 2-day workshop where ebCTC and USEPA visiting scientists exchanged information and ideas on concepts and computational tools for multiscale bionetwork modeling, from cell to organ

2006

October-December 2006

12/13/2006
*Computational Toxicology Tele-Seminar: Cheminformatics Tools for Toxicant Identification and Characterization (W. Welsh)

11/17/2006
ebCTC 2006 Overview Workshop at EOHSI: Visitors from USEPA met with and viewed presentations and posters by ebCTC scientists.

10/11/2006:
*Computational Toxicology Tele-Seminar: A closed-loop identification protocol (CLIP) for nonlinear biological networks (X-J. Feng, G. Li, H. Rabitz)

July-September 2006

9/29/2006
ArrayTrack Training at UMDNJ: Dr. Weida Tong, of USFDA-NCTR, provided hands-on training for ArrayTrack software at UMDNJ.

9/19/2006
ebCTC Science Day: New Methods and Tools of Computational Proteomics: The research team of Prof. Chris Floudas hosted a workshop on Computational Proteomics at Princeton University.

April-June 2006

6/14/2006
*Computational Toxicology Tele-Seminar: Computational Tools for the Source to Outcome Paradigm (P.G. Georgopoulos)

*Computational Toxicology Seminar Series
STAR Environmental Bioinformatic Centers Seminar Series at USEPA: In order to best interface the activities of the Environmental Bioinformatic Centers with the research being conducted within USEPA-ORD, an information program has been established. Each month, one of Centers presents an overview of the activities covered under one of their major projects. These sessions are open to all EPA staff who are interested in helping the Centers achieve their long-term objectives. While the number of interactions that can be developed are limited by available resources, these forums can facilitate the development of collaborative research projects. After the initial round of informational briefing, this program will evolve into a forum for presenting advances in environmental bioinformatics that will assist ORD in supporting the mission of the EPA of protecting human health and the environment.

Announcement of STAR Center Award
11/2/2005
News Release
EPA Announced an Award of $9 million to Establish Two Cutting-Edge Environmental Bioinformatics Research Centers