Recent and Upcoming Presentations (2007-2008)

(Note: this listing begins with the most recent work)

Protection and Restoration of the Environment IX (PRE9) Conference. June 29 - July 3, 2008, Kefalonia, Greece

• Mechanistic studies of environmental causes of human disease: a bionetwork dynamics modeling approach (P.G. Georgopoulos) [abstract]
• Modeling the impact of airport activities on local scale air quality (C. Efstathiou, A. Vemuri, S-W. Wang, P.G. Georgopoulos) [abstract]

The 2nd Annual Systems Toxicology Symposium: Multiscale Modeling, from Molecules to Organisms. April 30-May 1, 2008, Piscataway, NJ

Abstracts of the following presentations can be downloaded [570kb PDF].

• A multiscale framework for environmental systems toxicology (P.G. Georgopoulos)
• The indirect response model of arsenic exposure on gene expression  
  (M.A. Ovacik, M.G. Ierapetritou, P.G. Georgopoulos, W.J. Welsh, I.P. Androulakis)
• Gene expression studies of mouse skin response to sulfur mustard exposure for evaluating efficacy of inhibitors (D.R. Gerecke, M. Chen, S. Isukapalli, Y-C. Chang, W. Tong, I.P. Androulakis, P.G. Georgopoulos)
• Physiologically based inhalation dosimetry modeling for nanoparticles: Considerations of activity, age and gender (P. Shade, P.G. Georgopoulos)
• Efficient physiologically-based algorithms for estimating internal doses occuring due to chronic exposures of organics (S.S. Isukapalli, A.F. Sasso, P.G. Georgopoulos, K. Krishnan)
• User oriented implementation of a generalized Physiologically-Based Toxicokinetic (PBTK) modeling framework for mixtures (A.F. Sasso, P.G. Georgopoulos)
• Pharmacokinetic model of uptake and metabolism of arsenicals in hepatocytes with implications for reactive oxygen species generation and hepatocarcinogenesis (C.J. Brinkerhoff, S. Stamatelos, S.S. Isukapalli, P.G. Georgopoulos)
• Progress in developing infrastructure for a virtual liver I: Essential concepts and modules (P.G. Georgopoulos, W.J. Welsh, S.S. Isukapalli, M. Ierapetritou, I. Androulakis, C.M. Roth, W. Tong)
• Progress in developing infrastructure for a virtual liver II: Multi-scale studies of hepatotoxicants for elucidating potential biomarkers and important pathways related to hepatotoxicity (M. Chen, L. Schnackenberg, L. Guo, R. Holland, R. Beger, Q. Shi, S.S. Isukapalli, P.G. Georgopoulos, W.J. Welsh, W. Tong)
• Progress in developing infrastructure for a virtual liver V: PBTK/TD models with zonal and distributed parameters for metabolism of environmental toxins (S.S. Isukapalli, C.J. Brinkerhoff, A.F. Sasso, P.G. Georgopoulos)

USEPA Region 2 Seminar - Evaluating Fish Consumption Guidelines: A Qualitative and Quantitative Approach for High Risk Ethnic Groups. April 15, 2008, New York, NY

• Modeling dietary human exposures to mercury and methylmercury using a probabilistic source-to-dose approach (S.W. Wang, A. Sasso, Y.C. Yang, P.G. Georgopoulos J. Xue, T. McCurdy, H. Ozkaynak) [presentation]

International Conference on Health Sciences Simulation. April 14-17, 2008, Ottawa, Canada

• A physiologically-based algorithm for predicting internal dose of inhaled Toluene: Applications for high dose to low dose and rodent to human extrapolations (S.S. Isukapalli, K. Price, P.G. Georgopoulos, K. Krishnan)

47th Annual Meeting of the Society of Toxicology (SOT). March 16-20, 2008, Seattle, WA

• Toxicogenomic studies reveal the transsulfuration pathway as a possible mechanism for liver toxicity (M. Chen, L.K. Schnackenberg, L Guo, R. Holland, R.D. Beger, S. Isukapalli P.G. Georgopoulos, W.J. Welsh, W. Tong) [presentation]

MidSouth Computational Biology and Bioinformatics Society - MCBIOS 2008. February 23-24, 2008, Oklahoma City, OK

• Toxicogenomic studies reveal biosynthetic pathway of S-adenosylmethione as a possible hepatotoxic mechanism (M. Chen, L.K. Schnackenberg, L. Guo, R. Holland, R.D. Beger, Q. Shi, S. Isukapalli, P.G. Georgopoulos, W. Welsh, W. Tong) [abstract]

AIChE Annual Meeting. November 4-9, 2007, Salt Lake City, UT

• Toxicogenomics analysis following in utero exposure to di-butyl-phthalate (M.A. Ovacik, M.G. Ierapetritou, B. Sen, S. Euling, P.G. Georgopoulos, W. Welsh, K.W. Gaido, I.P. Androulakis) [abstract]
• A systematic toxicokinetic modeling framework for mixtures of toxic metals (A.F. Sasso, S.S. Isukapalli, P.G. Georgopoulos) [abstract]

Society of Environmental Toxicology and Chemistry (SETAC) Fall Workshop - Environmental Risk Assessment of Metals and Metalloids. October 26, 2007, Camden, NJ

• Integrating enviroinformatic and bioinformatic approaches for the systematic analysis of environmental human health risks from metals and metalloids (P.G. Georgopoulos, A.F. Sasso, S.S. Isukapalli) [abstract]
• Consistent physiologically based toxicokinetic modeling for mixtures of toxic metals and metalloids (A.F. Sasso, S.S. Isukapalli, P.G. Georgopoulos) [abstract]

First International Conference on Toxicogenomics Integrated with Environmental Sciences (TIES). October 25-26, 2007, Raleigh, NC

• Pathway activity analysis for transcriptional profiling of in utero exposure to d-n-butyl phthalate (M.A. Ovacik, M.G. Ierapetritou, P.G. Georgopoulos, W. Welsh, S. Euling, B. Sen, K. Gaido, I.P. Androulakis) [abstract | poster available upon request]
• ebTrack: an environmental bioinformatics system built upon ArrayTrack (M. Chen, S.S. Isukapalli, P.G. Georgopoulos, W.J. Welsh, W. Tong) [abstract | presentation available upon request]

17th Annual Meeting of the International Society of Exposure Analysis. October 14-18, 2007, Durham, NC

• Modeling personal and ambient exposures to air toxics in Camden, New Jersey (S.W. Wang, X. Tang, Z. Fan, P.J. Lioy, P.G. Georgopoulos) [abstract]
• Systems toxicology: multiscale modeling of environmental impacts on bionetworks (W.J. Welsh, P.G. Georgopoulos) [abstract]
• Exposure biology for a systems approach in studying environmental health risks (P.G. Georgopoulos, S.S. Isukapalli, W. Tong, P.J. Lioy, W.J. Welsh) [abstract]
• Comparative evaluation of population exposure modeling approaches for reactive and non-reactive air pollutants (S.S. Isukapalli, J.E. Langstaff, D.J. Lucken, P.G. Georgopoulos) [abstract]
• Characterizing chemical exposure from biomonitoring data using the Exposure Related Dose Estimating Model (ERDEM) (C.C. Dary, P.G. Georgopoulos, D.A. Vallero, R. Tornero-Velez, M. Morgan, M. Okino, M. Dellarco, F. Power, J.N. Blancato) [abstract]
• Characterizing exposures to arsenic and co-occurring contaminants using the Modeling Environment for TOtal Risk studies (MENTOR) (P.G. Georgopoulos, S.W. Wang, A.F. Sasso, S.S. Isukapalli) [abstract]
• Comparative evaluation of screening and computational fluid dynamics (CFD) approaches for modeling inhalation exposures in indoor environments (S.K. Stamatelos, P.G. Georgopoulos) [abstract]
• Comparative evaluation of three statistical data mining techniques (CART, MARS, and Random Forest) and their applications in analyzing the NHANES VOC project data (S.W. Wang, Y. Yan, P.G. Georgopoulos) [abstract]
• Sensitivity analysis for studying impacts of aging on population toxicokinetics and toxicodynamics (A.F. Sasso, S.S. Isukapalli, E. Kenyon, P.G. Georgopoulos) [abstract]
• Physiologically based toxicokinetic modeling for mixtures of toxic metals (A.F. Sasso, S.S. Isukapalli, P.G. Georgopoulos) [abstract]
• Evaluation of methods for reconstructing exposures from biomarkers via PBTK models (S.S. Isukapalli, A.F. Sasso, M. Okino, P.G. Georgopoulos) [abstract]

6th Annual CMAS Conference. Oct 1-3, 2007, Chapel Hill, NC

• Person oriented exposure modeling for ambient air toxics: High resolution modeling for local scale air quality (S.S. Isukapalli, P. George, S. Stamatelos, S.W. Wang, P.G. Georgopoulos) [abstract]
• Evaluation of emission control strategies for regional scale air quality: Performance of direct and surrogate techniques (S.S. Isukapalli, T. Kindap, A. Vemuri, S.W. Wang, P.G. Georgopoulos) [abstract]

USEPA NERL Exposure Reconstruction Workshop. September 12-14, 2007, Cincinnati, OH

• Optimized Bayesian and non-Bayesian inversion of biological data using mechanistic models (S.S. Isukapalli , A.F. Sasso, P.G. Georgopoulos)

ACC-LRI Workshop on VOC Exposure Modeling. June 20, 2007, Piscataway, NJ

• VOC inhalation exposure modeling in a “source to dose to effect” framework: Research directions and challenges (P.G. Georgopoulos) [presentation]
• VOC exposure research at USEPA-OAQPS (J. Langstaff, USEPA) [handout]
• Air toxics exposure modeling research at USEPA NERL: Linking air quality and exposure models (J. Burke, USEPA)
• Employing sub grid variability (SGV) properties of air quality models towards improving exposure assessments (J. Ching, USEPA) [presentaion]
• VOC exposure information from NJ DEP’s air monitoring network and special projects (L. Bonanno, NJDEP) [presentation]
• Issues in modeling population exposures to multiple, co-occurring airborne VOCs (S.S. Isukapalli) [presentation]
• VOC measurement considerations in developing exposure databases (C. Weisel) [presentation]
• Modeling exposures to VOCs via an individual-based approach: Bridging measurements and mechanistic modeling (S.W. Wang)
• Modeling exposures to VOCs via an individual-based approach part I: Application to the three RIOPA cities (S.W. Wang, X. Tang, N. Lahoti, S. Tong, S. S. Isukapalli, and P.G. Georgopoulos) [poster]
• Modeling exposures to VOCs via an individual-based approach part II: Application to an “air toxic hot-spot” area in Camden, NJ (S.W. Wang, X. Tang, Z. Fan, P.J. Lioy, and P.G. Georgopoulos) [poster]
• A modeling study of ambient VOC levels within the New Jersey Meadowlands district (S.W. Wang, X. Tang, N. Lahoti, S. Tong, S. S. Isukapalli, P. G. Georgopoulos) [poster]
• Modeling the impact of airport operations on local ambient levels of VOCs: Case study - Teterboro Airport, Bergen County NJ (C. Efstathiou, S. W. Wang, P.G. Georgopoulos, S. Tong, P.J. Lioy) [poster]
• Characterizing the relationship between personal exposures to VOCs and behavioral, socioeconomic, demographic variables: Analysis of NHANES VOC project data set (Y. Yan, S.W. Wang, and P.G. Georgopoulos) [poster]
• A unified platform for comparative application and analysis of local scale atmospheric dispersion models (N. Lahoti, S. Tong, S. S. Isukapalli and P. G. Georgopoulos) [poster]
• Evaluation of techniques for modeling local scale air quality (X. Tang, P. George, S.W. Wang, S. S. Isukapalli, P.G. Georgopoulos) [poster]
• Modeling the dispersion of volatile organic compounds (VOCs) in a furnished indoor space that includes human subjects – a computational fluid dynamics (CFD) approach (S. Stamatelos, P.G. Georgopoulos) [poster]
• Improving assessments of residential human exposures to chloroform via Bayesian PBTK modeling (Y.C. Yang, X. Xu, P.G. Georgopoulos) [poster]
• Assessing exposure and dose of VOCs using physiologically-based toxicokinetic models (A. Sasso, S.S. Isukapalli, P.G. Georgopoulos) [poster]

2007 International Science Forum on Computational Toxicology. May 21-23, 2007, Research Triangle Park, NC

• Environmental systems biology framework for human health risk analysis (P.G. Georgopoulos, S. Isukapalli, S-W. Wang, A. Sasso, M. Chen, W. Tong) [abstract | poster]
• Gene expression profiling following exposure to phthalate esters: an integrative toxicogenomics approach (M. Ovacik, M.G. Ierapetritou, I.P. Androulakis, B. Sen, S. Euling, K. Gaido, W. Welsh, P.G. Georgopoulos) [abstract | poster]
• Mechanistically consistent PBTK modeling framework for mixtures of toxic metals (A. Sasso, S. Isukapalli, P.G. Georgopoulos) [abstract | poster]
• NCTR Center for Toxicoinformatics - A Bioinformatics Resource for Genomics, Proteomics, Metabolomics, and Predictive Toxicology (W. Tong, L. Shi, S. Harris, H. Fang, M. Cao, R. Perkins) [abstract]
• Use of Toxicogenomics Data in Risk Assessment: A Case Study on Dibutyl Phthalate and Male Reproductive Developmental Effects (S. Euling, S. Makris, B. Sen, L. White, B. Benson, K.W. Gaido, A.S. Kim, S. Hester, V. Wilson, C. Keshava, N. Keshava, P.M. Foster, I.P. Androulakis, M. Ovacik, M.G. Ierapetritou, L.E. Gray Jr., C. Thompson, W. Chiu, W.J. Welsh, P.G. Georgopoulos) [abstract | poster]
• Shape Signatures: A Powerful New Technology for Risk Assessment (W.J. Welsh, V. Kholodovych, D. Chekmarev, P.G. Georgopoulos) [abstract | poster]

Meadowlands Symposium II. May 15-17, 2007, Lyndhurst, NJ

• Study of baseline quality of ambient air within the New Jersey Meadowlands District: Modeling components (S.W. Wang, X. Tang, N. Lahoti, S. Tong, S. Isukapalli, P.G. Georgopoulos) [abstract | presentation]
• Integrating enviroinformatic and bioinformatic approaches for the systematic analysis of environmentally related human health risks (P.G. Georgopoulos, P.J. Lioy, W.J. Welsh, S. Isukapalli, S.W. Wang) [abstract | poster]

ebCTC/DIMACS Workshop - Systems Toxicology: Multiscale Modeling of Environmental Impacts on Bionetworks. April 26-27, 2007, Piscataway, NJ

Abstracts of the following presentations can be downloaded.

• Overview presentation: An integrative framework for systems toxicology (P.G. Georgopoulos)
• Mechanistically consistent PBTK modeling framework for mixtures: application to toxic metals (A. Sasso, S. Isukapalli, P.G. Georgopoulos)
• Biologically based Bayesian reconstruction of human exposures from biomarker data: Application to chlorpyrifos (A. Sasso, S. Isukapalli, P.G.Georgopoulos)
• Transcriptional analysis following in utero exposure to dibutyl phthalate (DBP) esters (M.A. Ovacik, I.P. Androulakis, M.G. Ierapetritou, S. Euling, B. Sen, K.W. Gaido, W.J. Welsh, P.G. Georgopoulos)
• Classification of triazole conazole fungicides: pathway analysis (M.A. Ovacik, M.G. Ierapetritou, I.P. Androulakis, S. Nesnow, S. Hester, W. Welsh, P.G. Georgopoulos)
• Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect (D.R. Gerecke, M. Chen, S. Isukapalli, W. Tong, M.A. Ovacik, P.T. Foteinou, I.P. Androulakis, W. Welsh, P.G. Georgopoulos)
• Infrastructure for a virtual liver I: Essential concepts and modules (P.G. Georgopoulos, W.J. Welsh, S. Isukapalli, M. Ierapetritou, I. Androulakis, C.M. Roth, W. Tong)
• Infrastructure for a virtual liver III: Methods for metabolic analysis of xenobiotic interactions (S.A. Guzikowski, C.M. Roth, M.G. Ierapetritou, S. Isukapalli, P.G. Georgopoulos)

Society of Toxicology Annual Meeting and ToxExpo. March 25-29, 2007, Charlotte, NC

• Use of toxicogenomics data in risk assessment: A case study on dibutyl phthalate and male reproductive developmental effects (S.Y. Euling, S. Makris, B. Sen, A.S. Kim, B. Benson, K.W. Gaido, V.S. Wilson, C. Keshava, N. Keshava., L. White, P.M. Foster, I.P. Androulakis, M. Ovacik, M.G. Ierapetritou, L.E. Gray, C. Thompson, S. Barone, W. Chiu, W. Welsh, P.G. Georgopoulos) [poster]

USEPA Integrated Modeling Workshop. January 30, 2007, Research Triangle Park, NC

• Overview of an Integrated Modeling System for Supporting Multiscale Source-to-Effect Studies of Human Health Risks (P.G. Georgopoulos, S. Isukapalli, S.W. Wang) [presentation]

ORC Science Workshop at NJDEP "Progress Towards an Integrative Approach for Assessing Air Pollution Health Risks". January 26, 2007, Trenton, NJ

• Overview of Ozone Research Center Activities 2006: progress towards an integrative approach for assessing air pollution health risks (P.G. Georgopoulos, CCL Researchers) [presentation]
• Ozone Research Center activities in ambient air quality modeling: supporting the development of the NJDEP Ozone State Implementation Plan (Ozone SIP) (S. Isukapalli, A. Vemuri, P.G. Georgopoulos)
• Ozone trends at monitoring stations in New Jersey (CCL Researchers) [poster]
• PM2.5 trends at monitoring stations in New Jersey (CCL Researchers) [poster]
• Control strategies for ozone reduction in the MANE-VU region (A. Vemuri, S. Isukapalli, P.G. Georgopoulos) [poster]
• Study of baseline quality of ambient air within the New Jersey Meadowlands district: modeling components (S.W. Wang, X. Tang, N. Lahoti, S. Tong, S. Isukapalli, P. G. Georgopoulos) [poster]
• Individual-based exposure modeling to VOCs in three urban areas of the United States (S.W. Wang, X. Tang, N. Lahoti, S. Tong, S. Isukapalli, P.G. Georgopoulos) [poster]
• Computational Fluid Dynamics (CFD) for Indoor Air Quality (IAQ) modeling (S.K. Stamatelos, P.G. Georgopoulos) [poster]
• Using inhalation dosimetry models to predict deposition of ultrafine particles (P. Shade, P.G. Georgopoulos) poster]
• Development of a physiologically-based toxicokinetic (PBTK) framework for toxic metals and applications to inhalation and dietary exposure pathways (A. Sasso, S. Isukapalli, S.W. Wang, P.G. Georgopoulos) [poster]

Linking Ambient NO2 to Health Effects - Issues in Studying Human Exposures Workshop. January 11-12, 2007, Piscataway, NJ

• Current Status of NO2 Exposure Modeling and Related Research Needs (P.G. Georgopoulos, S.S. Isukapalli, A. Vemuri, L. Everett) [presentation | browse other presentations from this workshop]

Other Presentations: 2007-2008 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 & earlier

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