Peer Reviewed Journal Articles/Book Chapters

Recent Articles/Chapters

The following peer reviewed journal articles, from the past several years, are listed in reverse chronological order. Depending upon your access rights, most links will direct you to either the abstract or the full text of the article. To request a printed copy of any of these articles, please send an email request to Linda Everett.

• Xue J., Zartarian V., Wang S.W., Liu S.V. and Georgopoulos P.G. (2009 - in press). Probabilistic modeling of dietary arsenic exposure and dose and validation with 2003 NHANES data. Environmental Health Perspectives
• Krishnan K., Sasso A. and Georgopoulos P.G. (2009-in press). Pharmacokinetic mechanisms of interactions in chemical mixtures. In Principles and Practice of Mixture Toxicology (ISBN: 978-3-527-31992-3). Mumtaz, M. (ed.), John Wiley Publishers
• Georgopoulos P., Isukapalli S., Burke J., Napelenok S., Palma T., Langstaff J., Majeed M., He S., Byun D., Cohen M. and Vautard R. (2009). Air quality modeling needs for exposure assessment from the source-to-outcome perspective. Environmental Manager (October): 26-35. [link to article PDF] [link to A&WMA]
• Lioy P.J., Isukapalli S., Trasande L., Thorpe L., Dellarco M., Weisel C., Georgopoulos P.G., Yung C., Brown M. and Landrigan P. (2009). Using national and local extant data to characterize environmental exposures in the National Children’s Study (NCS): Queens County, New York. Environmental Health Perspectives 117(10): 1494-1504. [DOI link]
• Laumbach R., Harris G., Kipen H., Georgopoulos P., Shade P., Isukapalli S., Efstathiou C., Galea S., Vlahov D. and Wartenberg D. (2009). Respiratory symptoms are not associated with estimated WTC plume intensity and respiratory symptoms among residents outside of lower Manhattan. American Journal of Epidemiology 170(5): 640-649. [DOI link]
• Wang S.-W., Tang X., Fan Z., Lioy P.J. and Georgopoulos P.G. (2009). Modeling personal exposures from ambient air toxics in Camden, New Jersey: An evaluation study. Journal of the Air and Waste Management Association 59: 733-746. [DOI link]
• Yang Y., Xu X. and Georgopoulos P.G. (2009). A Bayesian population PBPK model for multiroute chloroform exposure. Journal of Exposure Science and Environmental Epidemiology (Advance Online Publication) [DOI link]
• Chen M., Martin J., Fang H., Isukapalli S., Georgopoulos P.G., Welsh W.J. and Tong W. (2009). ebTrack: an environmental bioinformatics system built upon ArrayTrack. BMC Proceedings 3 (Suppl 2): S5. [PubMed Link]
• Ierapetritou M.G., Georgopoulos P.G., Roth C.M. and Androulakis I.P. (2009). Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational research. Clinical and Translational Science 2 (3): 228-237.
  [DOI link]
• Georgopoulos P.G., Sasso A.F., Isukapalli S.S., Lioy P.J., Vallero D.A., Okino M. and Reiter L. (2009). Reconstructing population exposures to environmental chemicals from biomarkers: Challenges and opportunities. Journal of Exposure Science and Environmental Epidemiology 19 (2): 149-171. [DOI link]
• Gerecke D., Chen M., Isukapalli S., Gordon M.K., Chang Y.-C., Tong W., Androulakis I. and Georgopoulos P.G. (2009). Differential gene expression profiling of mouse skin after sulfur mustard exposure: extended time response and inhibitor effect. Toxicology and Applied Pharmacology 234 (2): 156-165 [DOI link]
  
• Zhu X., Fan Z., Wu X., Meng Q., Wang S.-W., Tang X., Ohman-Strickland P., Georgopoulos P., Zhang J., Bonanno L., Held J. and Lioy P. (2008). Spatial variation of volatile organic compounds in a "Hot Spot" for air pollution. Atmospheric Environment 42 (32): 7329-7338 [DOI link]
  
• Isukapalli S., Price K., Georgopoulos P.G. and Krishnan K. (2008). A physiologically-based algorithm for predicting internal dose of inhaled toluene: applications for high dose to low dose and rodent to human extrapolations. In: Proceedings of the 2008 Spring Simulation Multiconference - SpringSim 2008. (ISBN 1-56555-000-X). Rajaei, H., Wainer, G. A. and Chinni, M. J. (eds.) Ottawa, Canada, April 14-17, 2008. The Society for Computer Simulation International, San Diego. pp.583-588. [ACM link]
• Isukapalli S.S., Lioy P.J. and Georgopoulos P.G. (2008). Mechanistic modeling of emergency events: Assessing the impact of hypothetical releases of anthrax. Risk Analysis 28(3): 723-740 [DOI link]
• Georgopoulos P.G., Sasso A.F., Isukapalli S.S., Lioy P.J., Vallero D.A., Okino M. and Reiter L. (2008). Response to "µg/kg-day or µg/day: A commentary on Georgopoulos et al., JESEE 2008". J Expos Sci Environ Epidemiol 18 (6): 536-537 [DOI link]
• Georgopoulos P.G., Wang S.-W., Yang Y.-C., Xue J., Zartarian V.G., McCurdy T. and Ozkaynak H. (2008). Biologically based modeling of multimedia, multipathway, multiroute population exposures to arsenic. Journal of Exposure Science and Environmental Epidemiology 18: 462-476 [DOI link]
• Georgopoulos P. (2008). A multiscale approach for assessing the interactions of environmental and biological systems in a holistic health risk assessment framework. Water, Air, and Soil Pollution: Focus 8(1): 3-21 [DOI link]
• Lioy P.J., Vallero D., Foley G., Georgopoulos P., Heiser J., Watson T., Reynolds M., Daloia J., Tong S. and Isukapalli S. (2007). A personal exposure study employing scripted activities and paths in conjunction with atmospheric releases of perfluorocarbon tracers in Manhattan, New York. Journal of Exposure Science and Environmental Epidemiology 17(5): 409-425 [DOI link]
• Welsh W.J., Tong W. and Georgopoulos P.G. (2007). Toxicoinformatics: An Introduction. In Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals. Ekins, S. (ed.), Wiley: pp.153-182 [book link]
• Isukapalli S.S., Roy A. and Georgopoulos P.G. (2007). Physiologically Based Pharmacokinetic Modeling: Inhalation, Ingestion, and Dermal Absorption (Chapter 43). In Pharmacometrics: the Science of Quantitative Pharmacology. Ette, E. I. and Williams, P. J. (eds.), Wiley: pp.1069-1108 [book link]
• Georgopoulos P.G. and Lioy P.J. (2006). From theoretical aspects of human exposure and dose assessment to computational model implementation: The modeling environment for total risk studies (MENTOR). Journal of Toxicology and Environmental Health - Part B, Critical Reviews 9(6): 457-483 [DOI link]
• Lioy P.J. and Georgopoulos P. (2006). The anatomy of the exposures that occurred around the World Trade Center site: 9/11 and beyond. Annals of the New York Academy of Sciences 1076(1): 54-79 [DOI link]
• Cohen M., Sunderland E., Georgopoulos P.G., Wang S.W., Isukapalli S., Yang Y.C., Sasso A., Tong S., Xue J., McCurdy T., Zhang M., Sheldon L. and International Air Quality Advisory Board (2006). Development of a multicompartment mercury model for Lake Ontario: Tracking mercury from sources, deposition, and dispersion to fish to accumulation in humans. Chapter 2 in Priorities 2005 - Priorities and Progress Under the Great Lakes Water Quality Agreement. Windsor, Ontario, Canada, International Joint Commission (IJC): pp.39-69 [chapter link | full report]
• Georgopoulos P.G., Wang S.W., Lioy P.J., Georgopoulos I.G. and Yononne-Lioy M.J. (2006). Assessment of human exposure to copper: A case study using the NHEXAS database. Journal of Exposure Science and Environmental Epidemiology 16, 397–409 [DOI link]
• Stenchikov G., Lahoti N., Diner D., Kahn R., Lioy P.J. and Georgopoulos P.G. (2006). Multiscale plume transport from the collapse of the World Trade Center on September 11, 2001. Environmental Fluid Mechanics 6(5): 425-450 [DOI link |  this article in the news  ]
• Lioy P.J., Weisel C. and Georgopoulos P.G. (2006). An Overview of the Environmental Conditions and Human Exposures that Occurred Post 9-11. Chapter 2 in Urban Aerosols and Their Impacts: Lessons Learned from the World Trade Center Tragedy. Gaffney, J. S. and Marley, N. A. (eds.) Washington, D.C., American Chemical Society, Oxford University Press: pp.23-38 [book link]
• Vyas V.M., Sussman N., Gochfeld M., Georgopoulos P.G. and Lioy P.J. (2006). An evaluation of the role of risk based decision making in a former manufactured gas plant site remediation. Journal of the Air and Waste Management Association 56(2): 225-235 [abstract link]
• Vyas V.M., Roy A., Strawderman W., Georgopoulos P.G. and Kosson D.S. (2006). Development and application of methodologies for determining background groundwater quality at the Savannah River site. Journal of the Air and Waste Management Association 56(2): 159-168 [abstract link]
• Li G., Hu J., Wang S.W., Georgopoulos P.G., Schoendorf J. and Rabitz H. (2006). Random Sampling-High Dimensional Model Representation (RS-HDMR) and orthogonality of its different order component functions. Journal of Physical Chemistry A 110(7): 2474-2485 [DOI link]
• Hore P., Zartarian V., Xue J., Ozkaynak H., Wang S.-W., Yang Y.-C., Chu P.-L., Sheldon L., Robson M., Needham L., Barr D., Freeman N., Georgopoulos P. and Lioy P.J. (2006). Children's residential exposure to chlorpyrifos: Application of CPPAES field measurements of chlorpyrifos and TCPy within MENTOR/SHEDS pesticides model. Science of the Total Environment 366(2-3): 525-537 [DOI link]
• Wolff M.S., Teitelbaum S.L., Lioy P.J., Santella R.M., Wang R.Y., Jones R.L., Caldwell K.L., Sjodin A., Turner W.E., Li W., Georgopoulos P. and Berkowitz G.S. (2005). Exposures among pregnant women near the World Trade Center site on 11 September 2001. Environmental Health Perspectives 113(6): 739-748. [DOI link]
• Wang S.W., Georgopoulos P.G., Li G. and Rabitz H. (2005). Characterizing uncertainties in human exposure modeling through the Random Sampling - High Dimensional Model Representation (RS-HDMR) methodology. International Journal of Risk Assessment and Management 5: 387-406. [DOI link]
• Balakrishnan S., Roy A., Ierapetritou M.G., Flach G.P. and Georgopoulos P.G. (2005). A comparative assessment of efficient uncertainty analysis techniques for environmental fate and transport models: Application to the FACT model. Journal of Hydrology 307(1-4): 204-218. [DOI link]
• Wintermyer M., Skiadas A., Roy A., Yang Y.C., Georgapoulos P., Burger J. and Cooper K. (2005). The development of a physiologically-based pharmacokinetic model using the distribution of 2 317 8-tetrachlorodibenzo-p-dioxin in the tissues of the eastern oyster (Crassostrea virginica). Marine Environmental Research 60(2): 133-152 [DOI link]
• Georgopoulos P.G., Wang S.W., Vyas V.M., Sun Q., Burke J., Vedantham R., McCurdy T. and Ozkaynak H. (2005). A source-to-dose assessment of population exposures to fine PM and ozone in Philadelphia, PA, during a summer 1999 episode. Journal of Exposure Analysis and Environmental Epidemiology 15(5): 439-457 [DOI link]
• Wang S.W., Balakrishnan S. and Georgopoulos P.G. (2005). Fast equivalent operational model of tropospheric alkane photochemistry. American Institute of Chemical Engineers Journal 51(4): 1297-1303 [DOI link]
• Lazaridis M., Spyridaki A., Solberg S., Smolik J., Zdimal V., Eleftheriadis K., Aleksaropoulou V., Hov O. and Georgopoulos P.G. (2005). Mesoscale modeling of combined aerosol and photo-oxidant processes in the Eastern Mediterranean. Atmospheric Chemistry and Physics 5: 927-940 [SREF link]
• Lazaridis M., Spyridaki A., Solberg S., Kallos G., Svendby T., Flatoy F., Drossinos I., Housiadas C., Smolik J., Colbeck I., Varinou M., Gofa F., Eleftheriadis K., Zdimal V. and Georgopoulos P.G. (2004). Modeling of Combined Aerosol and Photooxidant Processes in the Mediterranean Area. Water, Air, & Soil Pollution: Focus V4(4): 3-21 [DOI link]
• Chandrasekar A., Philbrick C.R., Doddridge B., Clark R. and Georgopoulos P.G. (2004). A comparative study of prognostic MM5 meteorological model with aircraft, wind profiler, lidar, tethered balloon and RASS data over Philadelphia during a 1999 summer episode. Environmental Fluid Mechanics 4: 339-365 [DOI link]
• Georgopoulos P.G., Fedele P., Shade P., Lioy P., Hodgson M., Longmire J., Sands M. and Brown M.A. (2004). Hospital response to chemical terrorism: Personal protective equipment, training, and operations planning. American Journal of Industrial Medicine 46: 432-445 [DOI link]
• Landrigan P.J., Lioy P.J., Thurston G., Berkowitz G., Chen L.C., Chillrud S.N., Gavett S.H., Georgopoulos P.G., Geyh A.S., Levin S., Perera F., Rappaport S.M. and Small C. (2004). Health and environmental consequences of the World Trade Center disaster. Environmental Health Perspectives 112(6): 731-739 [DOI link]
• Ouyang M., Welsh W.J. and Georgopoulos P. (2004). Gaussian mixture clustering and imputation of microarray data. Bioinformatics 20(6): 917-23 [DOI link]
• Vyas V.M., Tong S.N., Uchrin C., Georgopoulos P.G. and Carter G.R. (2004). Geostatistical estimation of horizontal hydraulic conductivity for the Kirkwood-Cohansey aquifer. Journal of the American Water Resources Association 40(1): 187-195 [DOI link]
• Huber A., Georgopoulos P., Gilliam R., Stenchikov G., Wang S.-W., Kelly B. and Feingersh H. (2004). Modeling air pollution from the collapse of the World Trade Center and assessing the potential impacts on human exposures. Environmental Manager February 2004: 35-40 [journal link]
• Vette A., Gavett S., Perry S., Heist D., Huber A., Lorber M., Lioy P., Georgopoulos P., Rao S.T., Petersen W., Hicks B., Irwin J. and Foley G. (2004). Environmental research in response to 9/11 and homeland security. Environmental Manager February 2004: 14-22 [journal link]
• Balakrishnan S., Roy A., Ierapetritou M.G., Flach G.P. and Georgopoulos P.G. (2003). Uncertainty reduction and characterization of complex environmental fate and transport models: An empirical Bayesian framework incorporating the stochastic response surface method. Water Resources Research 39(12): 1350 [DOI link]
• Roy A., Ouyang M., Freeman N., Georgopoulos P.G. and Lioy P.J. (2003). Environmental, dietary, demographic, and activity variables associated with biomarkers of exposure for benzene and lead. Journal of Exposure Analysis and Environmental Epidemiology 13(6): 417-426 [DOI link]
• Foley G., Georgopoulos P.G. and Lioy P.J. (2003). Examining accountability for changes in population exposures to 8-hour ozone standard with implementation of different control strategies. Environmental Science and Technology 37(21): 302A-309A [issue link]
• Chandrasekar A., Philbrick C.R., Doddridge B., Clark R. and Georgopoulos P.G. (2003). A comparison study of RAMS simulations with aircraft, wind profiler, lidar, tethered balloon and RASS data over Philadelphia during a 1999 summer episode. Atmospheric Environment 37: 4973-4984 [DOI link]
• Chandrasekar A., Philbrick C.R., Clark R., Doddridge B. and Georgopoulos P.G. (2003). Evaluating the performance of a computationally efficient MM5/CALMET system for developing meteorological inputs to air quality models. Atmospheric Environment 37(23): 3267-3276 [DOI link]
• Chandrasekar A., Philbrick C.R., Clark R., Doddridge B. and Georgopoulos P.G. (2003). A large-eddy simulation study of the convective boundary layer over Philadelphia during the 1999 summer NE-OPS campaign. Environmental Fluid Mechanics 3(4): 305-329 [DOI link]
• Wang S.W., Georgopoulos P.G., Li G. and Rabitz H. (2003). Random Sampling-High Dimensional Model Representation (RS-HDMR) with nonuniformly distributed variables: Application to an integrated multimedia/multipathway exposure and dose model for trichloroethylene. Journal of Physical Chemistry A 107: 4707-4716 [DOI link]
• Li G., Rabitz H., Wang S.W. and Georgopoulos P.G. (2003). Correlation method for variance reduction of Monte Carlo integration in RS-HDMR. Journal of Computational Chemistry 24: 277-283 [DOI link]
• Li G., Artamonov M., Rabitz H., Wang S.W., Georgopoulos P.G. and Demiralp M. (2003). High dimensional model representations generated from low order terms - 1p-RS-HDMR. Journal of Computational Chemistry 24: 647-656 [DOI link]
• Balakrishnan S., Banerjee I., Georgopoulos P.G. and Ierapetritou M. (2002). Uncertainty considerations in the description of complex reaction systems. American Institute of Chemical Engineers Journal 48(12): 2875-2889 [DOI link]
• Weisel C., Cody R., Georgopoulos P., Purushothaman V., Weiss S., Bielory L., Gregory P. and Stern A. (2002). Concepts in developing health-based indicators for ozone. International Archives of Occupational and Environmental Health 75(6): 415-422 [DOI link]
• Georgopoulos P.G., Roy A., Yonone-Lioy M.J., Opiekun R.E. and Lioy P.J. (2001). Environmental copper: Its dynamics and human exposure issues. Journal of Toxicology and Environmental Health-Part B-Critical Reviews 4(4): 341-394 [DOI link]
• Lazaridis M., Broday D., Hov O. and Georgopoulos P.G. (2001). Integrated exposure and dose modeling and analysis system. 3. Deposition of inhaled particles in the human respiratory tract. Environmental Science and Technology 35: 3727-3734 [DOI link]
• Lazaridis M., Isukapalli S. and Georgopoulos P.G. (2001). Modeling of aerosol processes in plumes. Tellus Series B-Chemical and Physical Meteorology 53(1): 83-93 [DOI link]
• Drossinos Y., Kevrekedis P.G. and Georgopoulos P.G. (2001). Translational invariance in nucleation theories: Theoretical formulation. Physical Review E 63: 036123.1-036123.13 [DOI link]
• Broday D. and Georgopoulos P.G. (2001). Growth and deposition of hygroscopic particulate matter in the human lung. Aerosol Science and Technology 34: 144-159 [DOI link]

Selected Older Articles

• Isukapalli S., Roy A. and Georgopoulos P.G. (2000). Efficient sensitivity/uncertainty analysis using the combined stochastic response surface method (SRSM) and automatic differentiation for FORTRAN code (ADIFOR): Application to environmental and biological systems. Risk Analysis 20: 591-602 [DOI link]
• Kevrekidis P., Lazaridis M., Drossinos Y. and Georgopoulos P.G. (1999). A unified kinetic approach to binary nucleation. Journal of Chemical Physics 111: 8010-8012 [DOI link]
• Lazaridis M., Drossinos Y. and Georgopoulos P.G. (1998). Turbulent resuspension of small non-deformable particles. Journal of Colloid and Interface Science 204(1): 24-32. [DOI link]
• Wang S.W., Georgopoulos P.G., Li G. and Rabitz H. (1998). Condensing complex atmospheric chemistry mechanisms - 1: The direct constrained approximate lumping (DCAL) method applied to alkane photochemistry. Environmental Science and Technology 32: 2018-2024. [DOI link]
• Roy A. and Georgopoulos P.G. (1998) Reconstructing week-long exposures to volatile organic compounds using physiologically based pharmacokinetic models. Journal of Exposure Analysis and Environmental Epidemiology 8, 407-422 [journal link]
• Isukapalli S., Roy A. and Georgopoulos P.G. (1998) Stochastic response surface methods (SRSM) for uncertainty characterization and propagation: Application to environmental and biological systems. Risk Analysis 18(3) 351-363 [DOI link]
• Georgopoulos P.G., Arunachalam S. and Wang S. (1997). Alternative metrics for assessing the relative effectiveness of NOx and VOC emission reductions in controlling ground-level ozone. Journal of the Air and Waste Management Association 47(8): 837-850. [abstract link]
• Georgopoulos P.G., Purushothaman V. and Chiou R. (1997) Comparative evaluation of methods for estimating potential human exposure to pzone: Photochemical modeling and ambient monitoring. Journal of Exposure Analysis and Environmental Epidemiology 7: 191-215 [journal link]
• Georgopoulos P.G., Walia A., Roy A. and Lioy P.J. (1997). An integrated exposure and dose modeling and analysis system. 1. Formulation and testing of microenvironmental and pharmacokinetic components. Environmental Science and Technology 31(1): 17-27. [DOI link]
• Weisel C., Yu R., Roy A. and Georgopoulos P.G. (1996). Biomarkers for environmental benzene exposure. Environmental Health Perspectives 104(Suppl 6): 1141-1146. [PubMed link]
• Georgopoulos P.G. and Lioy P.J. (1996) Exposure measurement needs for hazardous waste sites: Two case studies. Toxicology and Industrial Health 12(5): 651-665 [journal link]
• McGrath L.F., Georgopoulos P.G. and Gallo M.A. (1996). Application of a biologically based RFD estimation method to tetrachlorodibenzo-p-dioxin (TCDD) mediated immune suppression and enzyme induction. Risk Analysis 16: 539-548 [DOI link]
• Roy A., Weisel C., Lioy P.J. and Georgopoulos P.G. (1996). A distributed parameter physiologically based pharmacokinetic model for dermal and inhalation exposure to volatile organic compounds. Risk Analysis 16: 147-160 [DOI link]
• Roy A., Weisel C.P., Gallo M.A. and Georgopoulos P.G. (1996) Studies of multi-route exposure/dose reconstruction using physiologically based pharmacokinetic models. Toxicology and Industrial Health 12: 153-163 [journal link]
• McGrath L.F., Georgopoulos P.G., Cooper K.R. and Gallo M.A. (1995). Alternative models for low dose-response analysis of biochemical and immunological endpoints for tetrachlorodibenzo-p-dioxin. Regulatory Toxicology and Pharmacology 21(3): 382-396 [DOI link]
• Georgopoulos P.G. (1995). Regulatory ozone modeling: Status, directions and research needs. Environmental Health Perspectives 103(Supplement 2): 107-132 [PubMed link]
• Georgopoulos P.G., Roy. A. and Gallo M.A. (1994) Reconstruction of short-term multi-route exposure to volatile organic compounds using physiologically based pharmacokinetic models. Journal of Exposure Analysis and Environmental Epidemiology 4: 309-328 [abstract link]
• Georgopoulos P.G. and Lioy P.J. (1994) Conceptual and theoretical aspects of human exposure and dose assessment. Journal of Exposure Analysis and Environmental Epidemiology 4: 253-285 [journal link]
• Moreno M.D., Cooper K.R., Brown R.P. and Georgopoulos P.G. (1992) A physiologically based pharmacokinetic model for Mya arenaria. Marine Environmental Research 34: 321-325 [DOI link]