CCL, a research unit of the Environmental and Occupational Health Sciences Institute (EOHSI), is dedicated to research in multiscale computational chemodynamics and toxicodynamics and environmental and biological informatics.
The research at CCL focuses on:
Computational Chemodynamics and Toxicodynamics: This involves the development, computational implementation, and application/evaluation of physically and physiologically based mathematical models of chemodynamic (environmental) and toxicodynamic (biological) processes (research area of mechanistic/prognostic modeling).
Environmental and Biological Informatics: This involves the development and/or application of computational tools for the mining, pattern recognition, and statistical analysis/interpretation of large, multivariate, environmental and biological datasets, with emphasis on environmental indicators and toxicogenomics applications (research area of phenomenological/diagnostic modeling).
Objective of the research efforts at CCL is the improvement of procedures for:
- Predicting transport/fate and quantifying concentrations/depositions of chemicals in multimedia environments (environmental modeling).
- Estimating multiroute/multipathway exposures of individuals and populations to toxics in various indoor and outdoor microenvironments (exposure modeling).
- Estimating internal doses for appropriate target tissues, using physiologically-based transport and toxicokinetic modeling (biological dosimetry modeling).
- Quantifying the effect of xenobiotic dose to cells, tissues, organs and the whole organism, using multiscale toxicodynamic modeling (dose-response analysis).
- Optimizing the information that can be extracted from complex datasets relevant to systems that involve environment-organism interactions (enviroinformatics and bioinformatics).
CCL’s efforts include exploring computer simulation-based alternatives to animal testing for risk assessment.